Two New Dioxopiperazine Derivatives, Arestrictins A and B, Isolated from Aspergillus restrictus and Aspergillus penicilloides

Takeshi Itabashi; Natsuna Matsuishi; Tomoo Hosoe; Norihiro Toyazaki; Shun-ichi Udagawa; Toshimichi Imai; Mitsuru Adachi; Ken-ichi Kawai

doi:10.1248/cpb.54.1639

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Two New Dioxopiperazine Derivatives, Arestrictins A and B, Isolated from Aspergillus restrictus and Aspergillus penicilloides

Takeshi Itabashi, Natsuna Matsuishi, Tomoo Hosoe, Norihiro Toyazaki, Shun-ichi Udagawa, Toshimichi Imai, Mitsuru Adachi, Ken-ichi Kawai

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Keywords: Aspergillus restrictus, Aspergillus penicilloides, dioxopiperazine, arestrictin A, arestrictin B, cristatin A

JOURNAL FREE ACCESS

2006 Volume 54 Issue 12 Pages 1639-1641

DOI https://doi.org/10.1248/cpb.54.1639

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Abstract

In the course of searching for bioactive substances, two new dioxopiperazine derivatives, arestrictins A (1) and B (2), were isolated along with the known dioxopiperazine, cristatin A (3), and the known peptide, asperglucide (4), from the organic extract of the xerophilic fungi, Aspergillus restrictus and Aspergillus penicilloides. The absolute structures of 1 and 2, except for the configuration of the secondary alcohol in 1, were established by spectroscopic and chemical investigation. The absolute configuration of cristatin A (3) was also determined.

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