Asymmetric Construction of Quaternary Carbon Stereocenter by Pd-Catalyzed Intramolecular α-Arylation

Takafumi Arao; Kazuhiro Kondo; Toyohiko Aoyama

doi:10.1248/cpb.54.1743

Notes

Asymmetric Construction of Quaternary Carbon Stereocenter by Pd-Catalyzed Intramolecular α-Arylation

Takafumi Arao, Kazuhiro Kondo, Toyohiko Aoyama

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Keywords: enantioselective intramolecular α-arylation, quaternary carbon, H₈-BINAP, chiral N-heterocyclic carbene

JOURNAL FREE ACCESS

2006 Volume 54 Issue 12 Pages 1743-1744

DOI https://doi.org/10.1248/cpb.54.1743

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Abstract

The catalyst comprised of Pd(OAc)₂ and H₈-BINAP provides good reaction conversions for a catalytic enantioselective intramolecular α-arylation of N-(2-bromophenyl)-N-methyl-2-arylpropanamide to form the quaternary carbon with up to 68% enantioselectivity.

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