Steroidal Glycosides from the Underground Parts of Solanum sodomaeum

Masateru Ono; Kazuya Nishimura; Keita Suzuki; Takeshi Fukushima; Keiji Igoshi; Hitoshi Yoshimitsu; Tsuyoshi Ikeda; Toshihiro Nohara

doi:10.1248/cpb.54.230

Notes

Steroidal Glycosides from the Underground Parts of Solanum sodomaeum

Masateru Ono, Kazuya Nishimura, Keita Suzuki, Takeshi Fukushima, Keiji Igoshi, Hitoshi Yoshimitsu, Tsuyoshi Ikeda, Toshihiro Nohara

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Keywords: Solanum sodomaeum, steroidal glycoside, solasodoside A, pregnane alkaloid, antiproliferative activity

JOURNAL FREE ACCESS

2006 Volume 54 Issue 2 Pages 230-233

DOI https://doi.org/10.1248/cpb.54.230

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Abstract

A new steroidal glycoside has been isolated from the underground parts of Solanum sodomaeum L., along with seven known steroidal glycosides. Their chemical structures were determined on the basis of spectroscopic data and chemical evidence, and the structure of one known pregnane type glycoside was corrected. In addition, their antiproliferative activity against human promyelocytic leukemia (HL-60) cells was investigated, and five compounds exhibited stronger activity than cisplatin.

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