Cytotoxic Polyprenylated Xanthones from the Resin of Garcinia hanburyi

Quan-Bin Han; Yu-Lin Wang; Ling Yang; Ting-Fai Tso; Chun-Feng Qiao; Jing-Zheng Song; Li-Jia Xu; Shi-Lin Chen; Da-Jian Yang; Hong-Xi Xu

doi:10.1248/cpb.54.265

Notes

Cytotoxic Polyprenylated Xanthones from the Resin of Garcinia hanburyi

Quan-Bin Han, Yu-Lin Wang, Ling Yang, Ting-Fai Tso, Chun-Feng Qiao, Jing-Zheng Song, Li-Jia Xu, Shi-Lin Chen, Da-Jian Yang, Hong-Xi Xu

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Keywords: Garcinia hanburyi, cytotoxicity, xanthone, multidrug resistance, gaudichaudic acid, isogambogenic acid

JOURNAL FREE ACCESS

2006 Volume 54 Issue 2 Pages 265-267

DOI https://doi.org/10.1248/cpb.54.265

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Abstract

Thirteen xanthones (1—13) were isolated from the resin of Garcinia hanburyi. Among them, two new compounds (namely gaudichaudic acid, and isogambogenic acid, 1, 2), and one new natural product (deoxygaudichaudione A, 3) were identified on the basis of extensive spectral evidence including detailed 2D NMR data. Ten of these xanthones were tested for their cytotoxicities against human leukemia K562 (K562/S) and doxorubicin-resistant K562 (K562/R) cell lines, and showed similar inhibitory effects on both cell lines, suggesting that this group of polyprenylated xanthones might not be multidrug resistance (MDR) substrates.

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