An Efficient Synthesis of 2-Benzoxepines from Morita–Baylis–Hillman Adducts Using Heterogeneous Recyclable Catalysts

Biswanath Das; Anjoy Majhi; Joydeep Banerjee; Nikhil Chowdhury; Harish Holla; Kankipati Harakishore; Upadhayula Suryanarayana Murty

doi:10.1248/cpb.54.403

Notes

An Efficient Synthesis of 2-Benzoxepines from Morita–Baylis–Hillman Adducts Using Heterogeneous Recyclable Catalysts

Biswanath Das, Anjoy Majhi, Joydeep Banerjee, Nikhil Chowdhury, Harish Holla, Kankipati Harakishore, Upadhayula Suryanarayana Murty

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Keywords: 2-benzoxepine, Morita–Baylis–Hillman adduct, formaldehyde, silica supported perchloric acid, Amberlyst-15, antibacterial activity

JOURNAL FREE ACCESS

2006 Volume 54 Issue 3 Pages 403-405

DOI https://doi.org/10.1248/cpb.54.403

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Abstract

2-Benzoxepines have efficiently been synthesized from Morita–Baylis–Hillman adducts, alkyl 3-aryl-3-hydroxy-2-methylenepropanoates by treatment with HCHO catalyzed by silica supported perchloric acid (HClO₄·SiO₂) or Amberlyst-15 in CH₂Cl₂ under reflux for a short period of time (1.5—2.5 h). The catalyst can be recovered and recycled. The antibacterial properties of the new 2-benzoxepines were studied but no activity was found.

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