Synthesis and Evaluation as NOP Ligands of Some Spiro[piperidine-4,2′(1′H)-quinazolin]-4′(3′H)-ones and Spiro[piperidine-4,5′(6′H)-[1,2,4]triazolo[1,5-c]quinazolines]

Carlo Mustazza; Anna Borioni; Isabella Sestili; Maria Sbraccia; Andrea Rodomonte; Rosella Ferretti; Maria Rosaria Del Giudice

doi:10.1248/cpb.54.611

Regular Articles

Synthesis and Evaluation as NOP Ligands of Some Spiro[piperidine-4,2′(1′H)-quinazolin]-4′(3′H)-ones and Spiro[piperidine-4,5′(6′H)-[1,2,4]triazolo[1,5-c]quinazolines]

Carlo Mustazza, Anna Borioni, Isabella Sestili, Maria Sbraccia, Andrea Rodomonte, Rosella Ferretti, Maria Rosaria Del Giudice

著者情報

キーワード: spiropiperidine, spiropiperidine triazoloquinazoline, nociceptin receptor ligand, opioid

ジャーナルフリー

2006 年 54 巻 5 号 p. 611-622

DOI https://doi.org/10.1248/cpb.54.611

詳細

抄録

Some spiro[piperidine-4,2′(1′H)-quinazolin]-4′(3′H)-ones 3 and spiro[piperidine-4,5′(6′H)-[1,2,4]triazolo[1,5-c]quinazolines] 4 were synthesized and evaluated as ligands of the nociceptin receptor. The examined compounds showed partial agonistic activity, except compounds 3, 4n that proved to be pure antagonists.

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