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Chemical and Pharmaceutical Bulletin
Vol. 54 (2006) No. 5 P 735-739




A new cyclic diarylheptanoid, acerogenin M (1), has been isolated along with nine known diarylheptanoids, 2—10, and two known phenolic compounds, 11 and 12, from a MeOH extract of the stem bark of Acer nikoense MAXIM. (Aceraceae). The structure of 1 was determined on the basis of a spectroscopic method. Upon evaluation of the inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 μg/ear) in mice of nine of the compounds (2—6, 8, 10—12), six (2, 4—6, 8, 10) showed a marked anti-inflammatory effect with a 50% inhibitory dose (ID50) of 0.26—0.81 mg per ear. In addition, upon an evaluation against the Epstein–Barr virus early antigen (EBV-EA) activation induced by TPA for all of the compounds, all exhibited moderate inhibitory effects against EBV-EA induction (IC50 values of 356—534 mol ratio/32 pmol TPA).

Copyright © 2006 The Pharmaceutical Society of Japan

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