Ginsenoside Rg₈, a New Dammarane-Type Triterpenoid Saponin from Roots of Panax quinquefolium

Abstract

A new dammarane-type triterpenoid saponin, ginsenoside Rg₈ (1), was isolated from the roots of Panax quinquefolium, along with five known saponins, (20E)-ginsenoside F₄ (2), ginsenosides Rh₁ (3), Rg₂ (4), F₁ (5), and (20R)-ginsenoside Rh₁ (6). The structure of ginsenoside Rg₈ (1) was determined to be (3β,6α,12β,20E)-24,25-epoxy-3,12,23-trihydroxydammar-20(22)-en-6-O-α-L-rhamnopyranosyl(1→2)-β-D-glucopyranoside by various spectroscopic analyses. Among the known saponins, (20E)-ginsenoside F₄ (2) and ginsenoside F₁ (5) were first reported from the title plant.