Cytotoxic Arylnaphthalene Lignans from Phyllanthus oligospermus

Abstract

Three new arylnaphthalene lignans, namely phyllanthusmins A—C, together with nine known compounds were isolated and characterized from the stems and roots of Phyllanthus oligospermus by a bioassay-guided purification. The structures of the new compounds were elucidated by means of spectroscopic data interpretation. Among them, phyllanthusminA displayed significant cytotoxicity against KB and P-388 cancer cell lines.