Asymmetric Synthesis of Methyl (−)-13-Oxo-15,16-dinorlabda-8(17),11E-dien-19-oate, Methyl Ester of a Potent Suppressor toward Carcinogenic Promotor

Takahiro Katoh; Shinsuke Mizumoto; Masato Fudesaka; Tetsuya Kajimoto; Manabu Node

doi:10.1248/cpb.54.1333

Notes

Asymmetric Synthesis of Methyl (−)-13-Oxo-15,16-dinorlabda-8(17),11E-dien-19-oate, Methyl Ester of a Potent Suppressor toward Carcinogenic Promotor

Takahiro Katoh, Shinsuke Mizumoto, Masato Fudesaka, Tetsuya Kajimoto, Manabu Node

著者情報

キーワード: (−)-13-oxo-15,16-dinorlabda-8(17),11E-dien-19-oic acid, Thuja standishii, synthesis, (−)-1,4a-dimethyl-5-oxodecahydronaphthalene-1-carboxylate

ジャーナルフリー

2006 年 54 巻 9 号 p. 1333-1337

DOI https://doi.org/10.1248/cpb.54.1333

詳細

抄録

Asymmetric synthesis of methyl ester (4) of (−)-13-oxo-15,16-dinorlabda-8(17),11E-dien-19-oic acid (1), which exhibited the most potent activity for the prevention of incipient carcinogenesis among the isolated diterpenes from Thuja standishii and its related plants, was achieved by using methyl (−)-1,4a-dimethyl-5-oxodecahydronaphthalene-1-carboxylate (5) as a strating material, which was easily prepared on gram scale by baker's yeast-catalyzed asymmetric reduction.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）