Bioactive Constituents from Chinese Natural Medicines. XX. Inhibitors of Antigen-Induced Degranulation in RBL-2H3 Cells from the Seeds of Psoralea corylifolia

Hisashi Matsuda; Sachiko Sugimoto; Toshio Morikawa; Koudai Matsuhira; Eri Mizuguchi; Seikou Nakamura; Masayuki Yoshikawa

doi:10.1248/cpb.55.106

Notes

Bioactive Constituents from Chinese Natural Medicines. XX. Inhibitors of Antigen-Induced Degranulation in RBL-2H3 Cells from the Seeds of Psoralea corylifolia

Hisashi Matsuda, Sachiko Sugimoto, Toshio Morikawa, Koudai Matsuhira, Eri Mizuguchi, Seikou Nakamura, Masayuki Yoshikawa

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Keywords: Psoralea corylifolia, degranulation inhibitor, Δ¹,3-hydroxybakuchiol, Δ³,2-hydroxybakuchiol, bavachin

JOURNAL FREE ACCESS

2007 Volume 55 Issue 1 Pages 106-110

DOI https://doi.org/10.1248/cpb.55.106

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Abstract

The ethyl acetate-soluble fraction of the methanolic extract from the seeds of Psoralea corylifolia was found to inhibit the release of β-hexosaminidase, as a marker of antigen-IgE-induced degranulation in RBL-2H3 cells. Sixteen constituents were isolated from the ethyl acetate-soluble fraction and several constituents, Δ¹,3-hydroxybakuchiol (IC₅₀=49 μM), Δ³,2-hydroxybakuchiol (69 μM, bavachin (58 μM), and psoralidin (ca. 100 μM), showed inhibitory activities against the antigen-induced degranulation.

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