Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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Lignans from Arctium lappa and Their Inhibition of LPS-Induced Nitric Oxide Production
So Young ParkSeong Su HongXiang Hua HanJi Sang HwangDongho LeeJai Seup RoBang Yeon Hwang
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2007 Volume 55 Issue 1 Pages 150-152

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Abstract

A new butyrolactone sesquilignan, isolappaol C (1), together with four known lignans, lappaol C (2), lappaol D (3), lappaol F (4), and diarctigenin (5), were isolated from the methanolic extract of the seeds from the Arctium lappa plant. The structure of isolappaol C (1) was determined by spectral analysis including 1D- and 2D-NMR. All the isolates were evaluated for their inhibitory effects on the LPS-induced nitric oxide production using murine macrophage RAW264.7 cells. Lappaol F (4) and diarctigenin (5) strongly inhibited NO production in the LPS-stimulated RAW264.7 cells with IC50 values of 9.5 and 9.6 μM, respectively.

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© 2007 The Pharmaceutical Society of Japan
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