Synthesis, Characterization and Antioxidant Activity of Naringenin Schiff Base and Its Cu(II), Ni(II), Zn(II) Complexes

Abstract

A new ligand, naringenin-2-hydroxy benzoyl hydrazone (H₅L), was prepared by condensation of naringenin with 2-hydroxy benzoyl hydrazine. Its Cu(II), Ni(II), Zn(II) complexes have also been synthesized and characterized on the basis of ¹H-NMR, IR, UV–Vis spectra, elemental analyses, molar conductivity and thermal analyses. The general formula of these complexes was M(H₃L) [M=Cu(II), Ni(II) and Zn(II)]. In addition, the antioxidant activities (superoxide and hydroxyl radical) of the free ligand and its complexes were determined in vitro. These compounds were found to possess potent antioxidant activity and be better than standard antioxidants like vitamin C and mannitol. In particular, the Cu(II) complex displayed excellent activity on the superoxide radical.