Notes
A Facile Synthesis of p- and m-(Amidinomethyl)phenyl Esters Derived from Amino Acid and Tryptic Hydrolysis of These Synthetic Inverse Substrates
2007 年 55 巻 10 号 p. 1514-1517
詳細
2007 年 55 巻 10 号 p. 1514-1517
A facile synthetic method for p- and m-(amidinomethyl)phenyl esters derived from a variety of amino acids is presented. We analyzed the kinetic behavior of trypsin towards these synthetic esters, which are inverse substrates. The substituent (meta- and para-isomers) and isosteric effects of (amidinomethyl)phenyl esters are discussed.
