Clerodane Diterpenoids and Flavonoids with NGF-Potentiating Activity from the Aerial Parts of Baccharis gaudichaudiana

Yuanqiang Guo; Yushan Li; Jing Xu; Ning Li; Tohru Yamakuni; Yasushi Ohizumi

doi:10.1248/cpb.55.1532

Notes

Clerodane Diterpenoids and Flavonoids with NGF-Potentiating Activity from the Aerial Parts of Baccharis gaudichaudiana

Yuanqiang Guo, Yushan Li, Jing Xu, Ning Li, Tohru Yamakuni, Yasushi Ohizumi

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Keywords: Baccharis gaudichaudiana, clerodane diterpene, flavone, nerve growth factor (NGF)-potentiating activity

JOURNAL FREE ACCESS

2007 Volume 55 Issue 10 Pages 1532-1534

DOI https://doi.org/10.1248/cpb.55.1532

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Abstract

A new clerodane diterpene, 15-hydroxy-16-acetoxy-ent-clerod-3-en-18-oic acid (1), together with three known clerodane diterpenes (2—4) and three known flavones (5—7), were isolated from the aerial parts of Baccharis gaudichaudiana. Their structures were elucidated on the basis of spectroscopic analysis. Compounds 2, 3, and 5 showed enhancing activity of nerve growth factor (NGF)-induced neurite outgrowth in PC 12D cells.

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