Enantioselective Intramolecular Aldol Reaction Mediated by a Combination of L-Amino Acid and Brønsted Acid to Construct a Bicyclic Enedione Containing a 7-Membered Ring

Abstract

The enantioselectivity of the intramolecular asymmetric aldol reaction of 1,3-cycloheptanedione bearing a C-2 methyl substituent, mediated by a series of combinations of L-amino acid and Brønsted acid, was examined in detail.