Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
Notes
Structural Development of Liver X Receptor (LXR) Antagonists Derived from Thalidomide-Related Glucosidase Inhibitors
Tomomi Noguchi-YachideHiroyuki MiyachiHiroshi AoyamaAtsushi AoyamaMakoto MakishimaYuichi Hashimoto
Author information
JOURNALS FREE ACCESS

Volume 55 (2007) Issue 12 Pages 1750-1754

Details
Download PDF (423K) Contact us
Abstract

Following our previous discovery of LXR antagonistic activity of 2′-substituted phenylphthalimides derived from thalidomide-related glucosidase inhibitors, structure–activity studies and further structural development led to 5-chloro-N-2′-n-pentylphenyl-1,3-dithiophthalimide (5CPPSS-50), with IC50 values of about 10 and 13 μM for LXRα and LXRβ, respectively.

Information related to the author
© 2007 The Pharmaceutical Society of Japan
Previous article Next article

Recently visited articles
feedback
Top