Synthesis and Evaluation of Urea and Thiourea Derivatives of Oxazolidinones as Antibacterial Agents

Sunil Kumar Reddy Aaramadaka; Mrinal kanthi Guha; Ganesh Prabhu; Suvarna Ganesh. Kini; Magesh Vijayan

doi:10.1248/cpb.55.236

Regular Articles

Synthesis and Evaluation of Urea and Thiourea Derivatives of Oxazolidinones as Antibacterial Agents

Sunil Kumar Reddy Aaramadaka, Mrinal kanthi Guha, Ganesh Prabhu, Suvarna Ganesh. Kini, Magesh Vijayan

著者情報

キーワード: oxazolidinone, antimicrobial agent, piperazine, structure activity relationship

ジャーナルフリー

2007 年 55 巻 2 号 p. 236-240

DOI https://doi.org/10.1248/cpb.55.236

詳細

抄録

Urea and thiourea derivatives of oxazolidinones were synthesized and their inhibitory activity (MIC) was determined on the bacterial strains which includes clinical isolates and quality control organisms. The structure activity relationships were studied and a 3D-QSAR model was built using Genetic Function Approximation. Interestingly found that electron withdrawing groups at the ortho position of the phenyl ring enhances the activity.

責任著者(Corresponding author)

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