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Chemical and Pharmaceutical Bulletin
Vol. 55 (2007) No. 3 P 455-458

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http://doi.org/10.1248/cpb.55.455

Notes

Two new flavonoid glycosides, 5-hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-β-D-glucopyranoside (1) and 5-hydroxy-7,8,2′,5′-tetramethoxy-flavone-5-O-β-D-glucopyranoside (2), and a new diterpenoid, andrographic acid (3), along with andrographidine A (4) were isolated from Andrographis paniculata, and their structures were determined on the basis of physicochemical and spectroscopic analysis. Compound 3 was evaluated for cytotoxicity to KB cells along with andrographolide, isoandrographolide, neoandrographolide and 14-deoxy-11,12-didehydroandrographolide obtained from A. paniculata in the present study. Cytotoxicity was observed for andrographolide and isoandrographolide with ED50 values of 6.5 and 5.1 μg/ml, respectively.

Copyright © 2007 The Pharmaceutical Society of Japan

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