Catalytic Activity of Silica Gels Bound Manganese(III)–Porphyrin on Oxidative Reaction of Adrenaline

Youji Kitamura; Tsutomu Takatsuki; Mayu Kawamoto; Madoka Saito; Akimasa Iwado; Ikuko Tsukamoto; Masaki Mifune; Yutaka Saito

doi:10.1248/cpb.55.500

Communications to the Editor

Catalytic Activity of Silica Gels Bound Manganese(III)–Porphyrin on Oxidative Reaction of Adrenaline

Youji Kitamura, Tsutomu Takatsuki, Mayu Kawamoto, Madoka Saito, Akimasa Iwado, Ikuko Tsukamoto, Masaki Mifune, Yutaka Saito

Author information

Youji Kitamura
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
Tsutomu Takatsuki
Department of Pharmaceutical Chemistry, Graduate School of Natural Science and Technology, Okayama University
Mayu Kawamoto
Department of Pharmaceutical Chemistry, Graduate School of Natural Science and Technology, Okayama University
Madoka Saito
Department of Pharmaceutical Chemistry, Graduate School of Natural Science and Technology, Okayama University
Faculty of Medicine, Kagawa University
Akimasa Iwado
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
Ikuko Tsukamoto
Faculty of Medicine, Kagawa University
Masaki Mifune
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
Yutaka Saito
Department of Pharmaceutical Sciences, Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University

Keywords: adrenaline, oxidation reaction, mimesis, oxidase, metal-porphyrin, silica gels

JOURNAL FREE ACCESS

2007 Volume 55 Issue 3 Pages 500-502

DOI https://doi.org/10.1248/cpb.55.500

Details

Abstract

To develop a solid catalysis on oxidative reaction of adrenaline (Ad), supports bound metal-tetrakis(4-carboxyphenyl)porphine (M-TCPP) were investigated. Silica gels bound Mn-TCPP were proved to has a superior activity in the oxidation of Ad and be able to serve as a useful oxidase model for Ad.

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