Two New Quinoline and Tris(4-hydroxycinnamoyl)spermine Derivatives from Microdesmis keayana Roots

Abstract

Purification of a Microdesmis keayana hydromethanolic root extract led to the isolation of two new natural compounds, xanthoquininamide (6-hydroxyquinoline-4-carboxamide) and tris(4-hydroxycinnamoyl)spermine (N⁵-(p-coumaroyl)-N¹,N¹⁴-diferuloylspermine) which was named keayanine. Their structures were determined using spectroscopic analyses (ESI-MS, 1D- and 2D-NMR).