Hydrolyzed Metabolites of Thalidomide: Synthesis and TNF-α Production-Inhibitory Activity

Takanori Nakamura; Tomomi Noguchi; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1248/cpb.55.651

Notes

Hydrolyzed Metabolites of Thalidomide: Synthesis and TNF-α Production-Inhibitory Activity

Takanori Nakamura, Tomomi Noguchi, Hiroyuki Miyachi, Yuichi Hashimoto

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Keywords: thalidomide, hydrolyzed thalidomide, metabolite, tumor necrosis factor (TNF)-α modulator

JOURNAL FREE ACCESS

2007 Volume 55 Issue 4 Pages 651-654

DOI https://doi.org/10.1248/cpb.55.651

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Abstract

Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-α production in the human monocytic leukemia cell line THP-1 was evaluated. α-(2-Carboxybenzamido)glutarimide was a more potent TNF-α production inhibitor than thalidomide.

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