An 18-Norspirostanol Saponin with Inhibitory Action against COX-2 Production from the Underground Part of Trillium tschonoskii

Junzhi Wang; Kun Zou; Yanming Zhang; Chuang Liu; Jun Wu; Yuan Zhou; Feijun Dan; Yaxiong Zhang

doi:10.1248/cpb.55.679

Notes

An 18-Norspirostanol Saponin with Inhibitory Action against COX-2 Production from the Underground Part of Trillium tschonoskii

Junzhi Wang, Kun Zou, Yanming Zhang, Chuang Liu, Jun Wu, Yuan Zhou, Feijun Dan, Yaxiong Zhang

著者情報

キーワード: Trillium tschonoskii, 18-norspirostanol saponin, COX-2, folk medicine, trillenoside A

ジャーナルフリー

2007 年 55 巻 4 号 p. 679-681

DOI https://doi.org/10.1248/cpb.55.679

詳細

抄録

A novel 18-norspirostanol saponin (1), along with Trillenoside A (2), was obtained from the underground parts of Trillium tschonoskii MAXIM., collected in Shennongjia Forest District, China. Based on the chemical and spectroscopic evidences, their structures were determined as shown in Fig. 1. 1 and 2 displayed marked inhibitory action towards COX-2 production in macrophagocytes of the mouse abdominal cavity stimulated by LPS at 10 μg/ml.

責任著者(Corresponding author)

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