Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Microbial Transformation of the Steroidal Alkaloid Dictyophlebine by Rhizopus stolonifer
Krishna Prasad DevkotaMuhammad Iqbal ChoudharySarfaraz Ahmed NawazAlain Meli LannangBruno Ndjakou LentaPatrice Aime FokouNorbert Sewald
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2007 Volume 55 Issue 4 Pages 682-684

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Abstract
The microbial transformation of a steroidal alkaloid, dictyophlebine (1) with Rhizopus stolonifer (ATCC 10404) afforded three oxidized metabolites 2—4. Compound 2 was found to be a new product. These metabolites were structurally characterized on the basis of modern spectroscopic techniques. Their inhibitory activity towards acetyl- and butyrylcholinesterase has been evaluated and the new product 2 has been found to be more potent than the parent compound and other metabolites.
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© 2007 The Pharmaceutical Society of Japan
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