Controlling 310-Helix and α-Helix of Short Peptides in the Solid State

Yosuke Demizu; Masakazu Tanaka; Masanobu Nagano; Masaaki Kurihara; Mitsunobu Doi; Tokumi Maruyama; Hiroshi Suemune

doi:10.1248/cpb.55.840

Communications to the Editor

Controlling 3₁₀-Helix and α-Helix of Short Peptides in the Solid State

Yosuke Demizu, Masakazu Tanaka, Masanobu Nagano, Masaaki Kurihara, Mitsunobu Doi, Tokumi Maruyama, Hiroshi Suemune

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Keywords: α,α-disubstituted amino acid, peptide, helix, conformation, secondary structure

JOURNAL FREE ACCESS

2007 Volume 55 Issue 5 Pages 840-842

DOI https://doi.org/10.1248/cpb.55.840

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Abstract

L-Leu hexapeptide containing α-aminoisobutyric acid (Aib) forms a right-handed (P) 3₁₀-helix, whereas that containing cyclic α,α-disubstituted amino acid Ac₅c^dOM assumes a right-handed (P) α-helix in the solid state.

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