Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Two New Sesquiterpenes from Alisma orientalis
Zhi-Yong Jiang, Xue-Mei Zhang, Jun Zhou, Feng-Xue Zhang, Ji-Jun Chen, Yang Lü, Li Wu, Qi-Tai Zheng
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Keywords: Alisma orientalis, sesquiterpenoid, alismorientol A, alismorientol B, anti-hepatitis B virus activity
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2007 Volume 55 Issue 6 Pages 905-907

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Abstract
Two new sesquiterpenoids named alismorientols A (1) and B (2) were isolated from the rhizomes of Alisma orientalis collected in Sichuan province, People's Republic of China. Their structures were elucidated based on spectroscopic analyses (1D and 2D NMR data including HSQC, HMBC, COSY, and ROESY) and X-ray crystallographic analysis. Anti-hepatitis B virus (HBV) bioassay revealed that compound 1 showed moderate anti-HBV activity in vitro with IC50 for HBsAg: 1.1 μM, for HBeAg: 14.7 μM.
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© 2007 The Pharmaceutical Society of Japan
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