Cytotoxic Constituents from the Leaves of Cinnamomum subavenium

Soong-Yu Kuo; Tian-Jye Hsieh; Yau-Der Wang; Wen-Li Lo; Yen-Ray Hsui; Chung-Yi Chen

doi:10.1248/cpb.56.97

Notes

Cytotoxic Constituents from the Leaves of Cinnamomum subavenium

Soong-Yu Kuo, Tian-Jye Hsieh, Yau-Der Wang, Wen-Li Lo, Yen-Ray Hsui, Chung-Yi Chen

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Keywords: Cinnamomum subavenium, subamolide D, subamolide E, secosubamolide A

JOURNAL FREE ACCESS

2008 Volume 56 Issue 1 Pages 97-101

DOI https://doi.org/10.1248/cpb.56.97

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Abstract

Two new butanolides, subamolide D (1) and subamolide E (2), and a new secobutanolide, secosubamolide A (3), along with 21 known compounds were isolated from the leaves of Cinnamomum subavenium. The structures of 1—3 were determined by spectroscopic analysis. Propidium iodide staining and cytometry analysis were used to evaluate the cell cycle progression of the treated SW480 cells and it was found that 1 and 2 caused DNA damage in a dose- and time-dependent manner.

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