Structural Development of Benzhydrol-Type 1′-Acetoxychavicol Acetate (ACA) Analogs as Human Leukemia Cell-Growth Inhibitors Based on Quantitative Structure–Activity Relationship (QSAR) Analysis

Takashi Misawa; Hiroshi Aoyama; Taniyuki Furuyama; Kosuke Dodo; Morihiko Sagawa; Hiroyuki Miyachi; Masahiro Kizaki; Yuichi Hashimoto

doi:10.1248/cpb.56.1490

Notes

Structural Development of Benzhydrol-Type 1′-Acetoxychavicol Acetate (ACA) Analogs as Human Leukemia Cell-Growth Inhibitors Based on Quantitative Structure–Activity Relationship (QSAR) Analysis

Takashi Misawa, Hiroshi Aoyama, Taniyuki Furuyama, Kosuke Dodo, Morihiko Sagawa, Hiroyuki Miyachi, Masahiro Kizaki, Yuichi Hashimoto

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Keywords: 1′-acetoxychavicol acetate, benzhydrol analog, HL-60, quantitative structure–activity relationship, molecular operating environment

JOURNAL FREE ACCESS

2008 Volume 56 Issue 10 Pages 1490-1495

DOI https://doi.org/10.1248/cpb.56.1490

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Abstract

Benzhydrol-type analogs of 1′-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure–activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (8) was a potent inhibitor with the IC₅₀ value of 0.12 μM.

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