Synthesis of the Key Intermediate, Diethyl 2-Acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the Immunomodulatory Agent FTY720 (Fingolimod)

Norimasa Matsumoto; Ryoji Hirose; Shigeo Sasaki; Tetsuro Fujita

doi:10.1248/cpb.56.595

Notes

Synthesis of the Key Intermediate, Diethyl 2-Acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate, of the Immunomodulatory Agent FTY720 (Fingolimod)

Norimasa Matsumoto, Ryoji Hirose, Shigeo Sasaki, Tetsuro Fujita

著者情報

キーワード: FTY720, immunomodulatory agent, Michael addition, fingolimod

ジャーナルフリー

2008 年 56 巻 4 号 p. 595-597

DOI https://doi.org/10.1248/cpb.56.595

詳細

抄録

The key intermediate, diethyl 2-acetylamino-2-(2-(4-octanoylphenyl)ethyl)propane-1,3-dioate (13), for the immunomodulatory agent FTY720 (2: fingolimod) was synthesized via Michael addition of diethyl(acetylamino)malonate (6) to 4-octanoylstyrene (12).

責任著者(Corresponding author)

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