One-Pot Synthesis of Simple Alkaloids: 2,3-Polymethylene-4(3H)-quinazolinones, Luotonin A, Tryptanthrin, and Rutaecarpine

Katherine Chae Jahng; Seung Ill Kim; Dong Hyeon Kim; Chang Seob Seo; Jong-Keun Son; Seung Ho Lee; Eung Seok Lee; Yurngdong Jahng

doi:10.1248/cpb.56.607

Notes

One-Pot Synthesis of Simple Alkaloids: 2,3-Polymethylene-4(3H)-quinazolinones, Luotonin A, Tryptanthrin, and Rutaecarpine

Katherine Chae Jahng, Seung Ill Kim, Dong Hyeon Kim, Chang Seob Seo, Jong-Keun Son, Seung Ho Lee, Eung Seok Lee, Yurngdong Jahng

Author information

Keywords: deoxyvasicinone, mackinazolinone, luotonin A, tryptanthrin, rutaecarpine, anthranilic acid

JOURNAL FREE ACCESS

2008 Volume 56 Issue 4 Pages 607-609

DOI https://doi.org/10.1248/cpb.56.607

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Abstract

One-pot synthesis of various 2,3-polymethylene-4(3H)-quinazolinones from anthranilic acid, corresponding lactam and SOCl₂ is described, which can be applicable to the synthesis of simple 4(3H)-quinazolinone-derived alkaloids, such as luotonin A, tryptanthrin, and rutaecarpine.

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