Myeloperoxidase Inhibitory and Radical Scavenging Activities of Flavones from Pterogyne nitens

Daniara Cristina Fernandes; Luis Octávio Regasini; José Carlos Rebuglio Vellosa; Patrícia Mendonça Pauletti; Ian Castro-gamboa; Vanderlan Silva Bolzani; Olga Maria Mascarenhas Oliveira; Dulce Helena Siqueira Silva

doi:10.1248/cpb.56.723

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Myeloperoxidase Inhibitory and Radical Scavenging Activities of Flavones from Pterogyne nitens

Daniara Cristina Fernandes, Luis Octávio Regasini, José Carlos Rebuglio Vellosa, Patrícia Mendonça Pauletti, Ian Castro-gamboa, Vanderlan Silva Bolzani, Olga Maria Mascarenhas Oliveira, Dulce Helena Siqueira Silva

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Keywords: flavone, Pterogyne nitens, myeloperoxidase, antioxidant, radical scavenging

JOURNAL FREE ACCESS

2008 Volume 56 Issue 5 Pages 723-726

DOI https://doi.org/10.1248/cpb.56.723

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Abstract

Two new flavone glucosides, nitensosides A and B (1, 2), together with four known compounds, sorbifolin (3), sorbifolin 6-O-β-glucopyranoside (4), pedalitin (5), and pedalitin 6-O-β-glucopyranoside (6) were isolated from Pterogyne nitens. Their structures were elucidated from 1D and 2D NMR analysis, as well as by high resolution mass spectrometry. All the isolated flavones were evaluated for their myeloperoxidase (MPO) inhibitory activity. The most active compound, pedalitin, exhibited IC₅₀ value of 3.75 nM on MPO. Additionally, the radical-scavenging capacity of flavones 1—6 was evaluated towards ABTS and DPPH radicals and compared to standard compounds quercetin and Trolox^®.

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