Neuritogenic Activity-Guided Isolation of a Free Base Form Manzamine A from a Marine Sponge, Acanthostrongylophora aff. ingens (Thiele, 1899)

Bo Zhang; Ryuichi Higuchi; Tomofumi Miyamoto; Rob W. M. Van Soest

doi:10.1248/cpb.56.866

Notes

Neuritogenic Activity-Guided Isolation of a Free Base Form Manzamine A from a Marine Sponge, Acanthostrongylophora aff. ingens (Thiele, 1899)

Bo Zhang, Ryuichi Higuchi, Tomofumi Miyamoto, Rob W. M. Van Soest

Author information

Keywords: marine sponge, Acanthostrongylophora ingens, manzamine-class alkaloid, free base form, neuritogenic activity, Neuro 2a

JOURNAL FREE ACCESS

2008 Volume 56 Issue 6 Pages 866-869

DOI https://doi.org/10.1248/cpb.56.866

Details

Abstract

Two manzamine-class alkaloids, manzamine A (1) and 8-hydroxymanzamine (2) were isolated from a Japanese marine sponge Acanthostrongylophora aff. ingens, together with three known alkaloids manzamine E (3), manzamine F (4), and manzamine X (5). The spectral features of 1 and 2 were different from the reported data. Detailed structure analysis using 2D NMR revealed the structure of 1 and 2 as a free base form of hydrochloric salt. These manzamine-class alkaloids showed neuritogenic activity against Neuro 2a cells.

Corresponding author

Register with J-STAGE for free!