Synthesis, Characterization, and the Antioxidative Activity of 4-{[(3,4-Dimethyl pyrrole-2-carbonyl)hydrazono](phenyl)methyl}-3-methyl-1-phenylpyrazol-5-ol and Its Zinc(II), Copper(II), Nickel(II) Complexes

Abstract

A new ligand H₃L, 4-{[(3,4-dimethylpyrrole-2-carbonyl)hydrazono](phenyl)methyl}-3-methyl-1-phenylpyrazol-5-ol and its three transition metal complexes, M(H₂L)OAc·H₂O (M=Cu, Ni), Zn(H₂L)₂ have been synthesized and fully characterized on the basis of ESI-MS, elemental analyses, molar conductivities, IR spectra and ¹H-NMR. In addition, their antioxidative activities have been investigated by spectrophotometer measurements. The experimental results show that the complexes have higher activity in the suppression of O₂^·− and ^·OH than the free ligand.