Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes

Midori Nishide; Yutaka Yoshikawa; Eriko U. Yoshikawa; Kinuyo Matsumoto; Hiromu Sakurai; Naemi M. KAJIWARA

doi:10.1248/cpb.56.1181

Notes

Insulinomimetic Zn(II) Complexes as Evaluated by Both Glucose-Uptake Activity and Inhibition of Free Fatty Acids Release in Isolated Rat Adipocytes

Midori Nishide, Yutaka Yoshikawa, Eriko U. Yoshikawa, Kinuyo Matsumoto, Hiromu Sakurai, Naemi M. KAJIWARA

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Keywords: Zn(II) complex, insulinomimetic activity, inhibition of free fatty acid-release, glucose-uptake activity

JOURNAL FREE ACCESS

2008 Volume 56 Issue 8 Pages 1181-1183

DOI https://doi.org/10.1248/cpb.56.1181

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Abstract

We prepared 4 new Zn(II) complexes with Zn(O₄), Zn(N₂O₂), and Zn(S₂O₂) coordination modes and evaluated their insulinomimetic activities in an in vitro study. The insulinomimetic activities of bis(pyrrole-2-carboxylato)zinc (Zn(pc)₂), bis(α-furonic acidato)zinc (Zn(fa)₂), bis(thiophene-2-carboxylato)zinc (Zn(tc)₂), and bis(thiophene-2-acetato)zinc (Zn(ta)₂) complexes were found to be higher than that of zinc sulfate (ZnSO₄). Zn(ta)₂ showed the highest insulinomimetic activity among the Zn(II) complexes because of its high lipophilicity.

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