Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Anti-human Immunodeficiency Virus-1 Protease Activity of New Lanostane-Type Triterpenoids from Ganoderma sinense
Naoto SatoQun ZhangChao-Mei MaMasao Hattori
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2009 Volume 57 Issue 10 Pages 1076-1080

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Abstract

Five new highly oxygenated lanostane-type triterpenoids [ganoderic acid GS-1 (1), ganoderic acid GS-2 (2), ganoderic acid GS-3 (3), 20(21)-dehydrolucidenic acid N (4) and 20-hydroxylucidenic acid A (5)] were isolated from the fruiting body of Ganoderma sinense, together with known compounds including 6 triterpenoids and 3 sterols. The structures of the new triterpenoids determined by spectroscopic means including 2D NMR were 7β-hydroxy-3,11,15-trioxo-lanosta-8,24(E)-dien-26-oic acid (1), 7β,15α-dihydroxy-3,11-dioxo-lanosta-8,24(E)-dien-26-oic acid (2), 12β-acetoxy-3β,7β-dihydroxy-11,15-dioxo-lanosta-8,24(E)-dien-26-oic acid (3), 3β,7β-dihydroxy-11,15-dioxo-25,26,27-trinorlanosta-8,20-dien-24-oic acid (4), and 7β,20ξ-dihydroxy-3,11,15-trioxo-25,26,27-trinorlanost-8-en-24-oic acid (5), respectively. Among these, ganoderic acid GS-2, 20-hydroxylucidenic acid N, 20(21)-dehydrolucidenic acid N and ganoderiol F inhibited human immunodeficiency virus-1 protease with IC50 values of 20—40 μM.

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© 2009 The Pharmaceutical Society of Japan
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