Abstract
A new class of sulfone-linked bis heterocycles, methyl-3-(4′-aryl-1′H-pyrazol-3′-ylsulfonyl)-4-aryl-3H-pyrrole-3-carboxylate (8), methyl-3-(1′-phenyl-3′,5′-diaryl-1′H-pyrazol-4′-ylsulfonyl)-4-aryl-3H-pyrrole-3-carboxylate (9) and methyl-3-(3′,5′-diarylisoxazol-4′-ylsulfonyl)-4-aryl-3H-pyrrole-3-carboxylate (10) were prepared by the regioselective reaction of methyl-3-aryl-2-(E-arylethenesulfonyl)acrylate (2) with tosylmethyl isocyanide followed by fuctionalization of olefin moiety with 1,3-dipolar reagents. The lead compounds were tested for their antimicrobial activity.
