Novel System for Decarboxylative Bromination of α,β-Unsaturated Carboxylic Acids with Diacetoxyiodobenzene

Ravindra Abhykumar Fursule; Pravin Onkar Patil; Bharti Devaji Shewale; Satish Bhaskar Kosalge; Prashant Krishnarao Deshmukh; Dilip Ashok Patil

doi:10.1248/cpb.57.1243

Regular Articles

Novel System for Decarboxylative Bromination of α,β-Unsaturated Carboxylic Acids with Diacetoxyiodobenzene

Ravindra Abhykumar Fursule, Pravin Onkar Patil, Bharti Devaji Shewale, Satish Bhaskar Kosalge, Prashant Krishnarao Deshmukh, Dilip Ashok Patil

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Keywords: diacetoxyiodobenzene, α,β-unsaturated carboxylic acid, tetraethyl-ammonium bromide, bromoalkene

JOURNAL FREE ACCESS

2009 Volume 57 Issue 11 Pages 1243-1245

DOI https://doi.org/10.1248/cpb.57.1243

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Abstract

A simple and mild method for the conversion of varieties of α,β-unsaturated carboxylic acids to the corresponding bromoalkenes using diacetoxyiodobenzene (IBD) in combination with tetraethyl-ammonium bromide (TEAB) at room temperature is discussed. Advantages of this system are short reaction time, easy work up and gave good to excellent yields.

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