Isolation and Identification of a Novel Chlorophenol from a Cell Suspension Culture of Helichrysum aureonitens

Seyed Mahdi Ziaratnia; Kiyoshi Ohyama; Ahmed Abdel-Fattah Hussein; Toshiya Muranaka; Namrita Lall; Karl Josef Kunert; Jacobus Johannes Marion Meyer

doi:10.1248/cpb.57.1282

Notes

Isolation and Identification of a Novel Chlorophenol from a Cell Suspension Culture of Helichrysum aureonitens

Seyed Mahdi Ziaratnia, Kiyoshi Ohyama, Ahmed Abdel-Fattah Hussein, Toshiya Muranaka, Namrita Lall, Karl Josef Kunert, Jacobus Johannes Marion Meyer

著者情報

キーワード: Helichrysum aureonitens, polyacetylene, cell suspension, chlorophenol, anticancer

ジャーナルフリー

2009 年 57 巻 11 号 p. 1282-1283

DOI https://doi.org/10.1248/cpb.57.1282

詳細

抄録

A novel chlorophenol, 4-chloro-2-(hepta-1,3,5-triyn-1-yl)-phenol (1), was isolated as the major phenolic compound from the cells of Helichrysum aureonitens suspension cultures. Compound 1 has been proposed to be an intermediate in the acetylene biosynthetic pathway of other acetylenic compounds in Helichrysum spp. The ethanol extract of cell suspension cultures and compound 1 were evaluated for their cytotoxicity against monkey kidney Vero (Vero cells) and human prostate epithelial carcinoma (DU145) cell lines, also, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Mycobacterium tuberculosis H37Rv were determined as well.

責任著者(Corresponding author)

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