Cytotoxic Sorbicillinoids and Bisorbicillinoids from a Marine-Derived Fungus Trichoderma sp.

Lin Du; Tianjiao Zhu; LiYuan Li; Shengxin Cai; Boyu Zhao; Qianqun Gu

doi:10.1248/cpb.57.220

Notes

Cytotoxic Sorbicillinoids and Bisorbicillinoids from a Marine-Derived Fungus Trichoderma sp.

Lin Du, Tianjiao Zhu, LiYuan Li, Shengxin Cai, Boyu Zhao, Qianqun Gu

Author information

Keywords: Trichoderma sp., sorbicillinoid, bisorbicillinoid

JOURNAL FREE ACCESS

2009 Volume 57 Issue 2 Pages 220-223

DOI https://doi.org/10.1248/cpb.57.220

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Abstract

Four sorbicillinoids (1—4) and seven bisorbicillinoids (5—11), including two new compounds, 6-demethylsorbicillin (1) and 10,11-dihydrobisvertinolone (6), were isolated from a marine-derived fungus Trichoderma sp. Their cytotoxic activities against HL-60 cell line were evaluated by Sulforhodamine B (SRB) assay method and flow cytometric analysis.

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