2009 年 57 巻 4 号 p. 397-400
Two new flavan-3-ols, 6-(2-pyrrolidinone-5-yl)-(−)-epicatechin (1) and 8-(2-pyrrolidinone-5-yl)-(−)-epicatechin (2), as well as five known compounds, (−)-epicatechin (3), (+)-catechin (4), proanthocyanidin B-4 (5), (+)-pinoresinol, and p-hydroxybenzoic acid, were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation, particularly by extensive 1D- and 2D-NMR studies. All the isolates were evaluated in vitro for inhibitory activity on the formation of advanced glycation end products (AGEs). Of these, compounds 1—5 exhibited significant inhibitory activity against AGEs formation with IC50 values ranging from 10.1 to 125.2 μM.
