Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Two New Sesquiterpenoids from Solanum lyratum with Cytotoxic Activities
Yan RenLi ShenDe-Wu ZhangSheng-Jun Dai
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2009 Volume 57 Issue 4 Pages 408-410

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Abstract

Two new sesquiterpenoids, lyratol C (1) and lyratol D (2), together with two known sesquiterpenoids, dehydrovomifoliol (3) and blumenol A (4), were isolated from the whole plant of Solanum lyratum. Their structures were established by spectroscopic analyses. In vitro, the four compounds showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and gave IC50 values in the range 3.7—8.1 μM.

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© 2009 The Pharmaceutical Society of Japan
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