Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Conferols A and B, New Anti-inflammatory 4-Hydroxyisoflavones from Caragana conferta
Rehan KhanAbdul MalikAchyut AdhikariMohammad Irfan QadirMuhammad Iqbal Choudhary
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2009 Volume 57 Issue 4 Pages 415-417

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Abstract
Conferols A (1) and B (2), the new 4-hydroxyisoflavones, have been isolated from the dichloromethane sub-fraction of the methanolic extract of Caragana conferta along with 3′,5′-dihydroxy, 7,4′-dimethoxyisoflavone (3), E-cinnamic acid (4), tetracosyl 3,4-dihydroxy-E-cinnamate (5), docosyl 3,4-dihydroxy-E-cinnamate (6), β-sitosterol (7), β-sitostrerol 3-O-β-D-glucopyranoside (8), stigmasterol (9) and lupeol (10), respectively, reported for the first time from this species. The structures of the new compounds were elucidated through spectroscopic techniques including MS and 2D-NMR. The compounds 1—3 showed significant anti-inflammatory activity in the respiratory burst assay.
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© 2009 The Pharmaceutical Society of Japan
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