Synthesis of Some New Spiropyranoquinolines and Evaluation of Their Free Radical Scavenging Activity

Vassiliki Panteleon; Ioannis K. Kostakis; Panagiotis Marakos; Nicole Pouli; Ioanna Andreadou

doi:10.1248/cpb.57.446

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Synthesis of Some New Spiropyranoquinolines and Evaluation of Their Free Radical Scavenging Activity

Vassiliki Panteleon, Ioannis K. Kostakis, Panagiotis Marakos, Nicole Pouli, Ioanna Andreadou

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Keywords: quinoline, spiropyranoquinoline, radical scavenging activity, antioxidant activity

JOURNAL FREE ACCESS

2009 Volume 57 Issue 5 Pages 446-452

DOI https://doi.org/10.1248/cpb.57.446

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Abstract

The preparation of some new spiro-substituted 4-hydroxypyranoquinolinones and their corresponding dihydropyrano cis-diols is described. The free radical scavenging activity of the compounds was determined by means of their interaction with the stable free radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the superoxide anions generated by the enzymic xanthine–xanthine oxidase system. The spiroadamatylpyranoquinolinone analogue proved to be the most efficient free radical scavenger.

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