Prenylflavonols from the Leaves of Macaranga sampsonii

Xiaohua Li; Liangxiong Xu; Ping Wu; Haihui Xie; Zhongliang Huang; Wanhui Ye; Xiaoyi Wei

doi:10.1248/cpb.57.495

Regular Articles

Prenylflavonols from the Leaves of Macaranga sampsonii

Xiaohua Li, Liangxiong Xu, Ping Wu, Haihui Xie, Zhongliang Huang, Wanhui Ye, Xiaoyi Wei

Author information

Xiaohua Li
Key Labotatory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences
Graduate School of Chinese Academy of Sciences
Liangxiong Xu
Key Labotatory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences
Ping Wu
Key Labotatory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences
Haihui Xie
Key Labotatory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences
Zhongliang Huang
Key Labotatory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences
Wanhui Ye
Key Labotatory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences
Xiaoyi Wei
Key Labotatory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences

Keywords: Macaranga sampsonii, Macaranga, prenylflavonol, flavonoid

JOURNAL FREE ACCESS

2009 Volume 57 Issue 5 Pages 495-498

DOI https://doi.org/10.1248/cpb.57.495

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Abstract

Four novel prenylflavonols, macaranones A—D (1—4), were isolated from the leaves of Macaranga sampsonii. Their structures were elucidated on the basis of spectroscopic data. Macaranones C (3) and D (4) represent first two examples of flavonols having an unusual peltogynoid skeleton which is formed from a 2′-geranylflavonol by cyclization between 3-OH and C-1″ of the 2′-geranyl substituent of the flavonol. Compounds 1—4 were evaluated for the cytotoxicity against several human cancer cell lines.

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