Studies on the Constituents of Whole Plants of Youngia japonica

Emiko Yae; Shoji Yahara; Mona El-Aasr; Tsuyoshi Ikeda; Hitoshi Yoshimitsu; Chikako Masuoka; Masateru Ono; Izumi Hide; Yoshihiro Nakata; Toshihiro Nohara

doi:10.1248/cpb.57.719

Regular Articles

Studies on the Constituents of Whole Plants of Youngia japonica

Emiko Yae, Shoji Yahara, Mona El-Aasr, Tsuyoshi Ikeda, Hitoshi Yoshimitsu, Chikako Masuoka, Masateru Ono, Izumi Hide, Yoshihiro Nakata, Toshihiro Nohara

Author information

Emiko Yae
Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
Shoji Yahara
Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
Mona El-Aasr
Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
Tsuyoshi Ikeda
Faculty of Medical and Pharmaceutical Sciences, Kumamoto University
Hitoshi Yoshimitsu
Faculty of Pharmaceutical Sciences, Sojo University
Chikako Masuoka
School of Agriculture, Tokai University
Masateru Ono
School of Agriculture, Tokai University
Izumi Hide
Graduate School of Biomedical Sciences, Hiroshima University
Yoshihiro Nakata
Graduate School of Biomedical Sciences, Hiroshima University
Toshihiro Nohara
Faculty of Pharmaceutical Sciences, Sojo University

Keywords: Youngia japonica, antiallergic, guaiane, phenylpropanoid

JOURNAL FREE ACCESS

2009 Volume 57 Issue 7 Pages 719-723

DOI https://doi.org/10.1248/cpb.57.719

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Abstract

Two new guaiane-type sesquiterpene (1, 2), 2 new phenylpropanoid derivatives (3, 4), and 5-oxo-11-hydroxy-8(Z)-undecenoic acid 11-O-glucoside (5), together with 17 known compounds have been isolated from the whole plants of Youngia japonica (L.) Dc., which have been known to be used as folk medicines to treat people suffering from atopy. The guaiane-type sesquiterpene, grosheimin (17) exhibited strong antiallergic and antioxidant activities.

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