Two Flavonoid Dimers from Sarcandra hainanensis (PEI) SWAMY et BAILEY

Cong-Mei Cao; Yong Peng; Li-Jia Xu; Ya-Jun Wang; Jun-Shan Yang; Pei-Gen Xiao

doi:10.1248/cpb.57.743

Notes

Two Flavonoid Dimers from Sarcandra hainanensis (PEI) SWAMY et BAILEY

Cong-Mei Cao, Yong Peng, Li-Jia Xu, Ya-Jun Wang, Jun-Shan Yang, Pei-Gen Xiao

Author information

Cong-Mei Cao
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education
Yong Peng
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education
Li-Jia Xu
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education
Ya-Jun Wang
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College
Jun-Shan Yang
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College
Pei-Gen Xiao
Institute of Medicinal Plant Development, Chinese Academy of Medical Science, Peking Union Medical College
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Peking Union Medical College), Ministry of Education

Keywords: flavonoid dimer, flavan-chalcone, Sarcandra hainanensis, Chloranthaceae, human immunodeficiency virus-1 integrase inhibition

JOURNAL FREE ACCESS

2009 Volume 57 Issue 7 Pages 743-746

DOI https://doi.org/10.1248/cpb.57.743

Details

Abstract

Two new flavonoid dimers (1, 2) consisting of flavan-chalcone together with three known compounds (3—5) were isolated from the ethanol extract of the whole plants of Sarcandra hainanensis. Their structures were determined by extensive spectroscopic analysis. Human immunodeficiency virus-1 integrase inhibition activities of compounds 1 and 2 were evaluated and they showed weak activities with IC₅₀ at 18.05 and 25.27 μM, respectively.

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