Diketopiperazine Alkaloids from a Deep Ocean Sediment Derived Fungus Penicillium sp.

Lin Du; Xinying Yang; Tianjiao Zhu; Fengping Wang; Xiang Xiao; Hyun Park; Qianqun Gu

doi:10.1248/cpb.57.873

Notes

Diketopiperazine Alkaloids from a Deep Ocean Sediment Derived Fungus Penicillium sp.

Lin Du, Xinying Yang, Tianjiao Zhu, Fengping Wang, Xiang Xiao, Hyun Park, Qianqun Gu

Author information

Lin Du
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China
Xinying Yang
Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine
Tianjiao Zhu
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China
Fengping Wang
Key Laboratory of Marine Biogenetic Resources, the Third Institute of Oceanography, the State Oceanic Administration
Xiang Xiao
Key Laboratory of Marine Biogenetic Resources, the Third Institute of Oceanography, the State Oceanic Administration
Hyun Park
Department of Infection Biology, Zoonosis Research Center, Wonkwang University School of Medicine
Qianqun Gu
Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China

Keywords: Penicillium sp., diketopiperazine, brevicompanine

JOURNAL FREE ACCESS

2009 Volume 57 Issue 8 Pages 873-876

DOI https://doi.org/10.1248/cpb.57.873

Details

Abstract

Five new diketopiperazine alkaloids, brevicompanines D—H (3—7), together with two known analogs, allo-brevicompanine B (1) and fructigenine B (2), were isolated from a deep ocean sediment derived fungus Penicillium sp. Their structures were established by spectroscopic methods including 2D NMR and chiral HPLC analysis. Compounds 4 and 7 inhibited lipopolysaccharide (LPS)-induced nitric oxide production in BV2 microglial cells.

Corresponding author

Register with J-STAGE for free!