Deoxymanoalides from the Nudibranch Chromodoris willani

Mohammad Helal Uddin; Masahito Otsuka; Toshinobu Muroi; Atsushi Ono; Novriyandi Hanif; Seiko Matsuda; Tatsuo Higa; Junichi Tanaka

doi:10.1248/cpb.57.885

Notes

Deoxymanoalides from the Nudibranch Chromodoris willani

Mohammad Helal Uddin, Masahito Otsuka, Toshinobu Muroi, Atsushi Ono, Novriyandi Hanif, Seiko Matsuda, Tatsuo Higa, Junichi Tanaka

著者情報

キーワード: manoalide, Chromodoris willani, phospholipase A2

ジャーナルフリー

2009 年 57 巻 8 号 p. 885-887

DOI https://doi.org/10.1248/cpb.57.885

詳細

抄録

Two sesterterpenes, deoxymanoalide (1) and deoxysecomanoalide (2), were isolated from the nudibranch Chromodoris willani collected in Okinawa and their structures determined on the basis of spectroscopic data and chemical conversions. The mollusk feeds on a sponge containing manoalide (3) and secomanoalide (4) and is likely to biotransform them into 1 and 2. Both 1 and 2 showed moderate antimicrobial activity against Escherichia coli and Bacillus subtilis and inhibited snake venom phospholipase A2 at 0.2 to 0.5 μM.

責任著者(Corresponding author)

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