Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
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Vibralactones D—F from Cultures of the Basidiomycete Boreostereum vibrans
Meng-Yuan JiangLing ZhangZe-Jun DongZhu-Liang YangYing LengJi-Kai Liu
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2010 Volume 58 Issue 1 Pages 113-116

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Abstract

Three new metabolites, vibralactones D—F (1—3) were isolated from cultures of the basidiomycete Boreostereum vibrans. The relative configuration of 1 was established on the basis of X-ray diffraction analysis, while the absolute configurations of 1—3 were assigned using a modified Mosher's method. Compound 1 showed weak inhibitory activities against isozymes of 11β-hydroxysteroid dehydrogenases (HSD) with IC50 values of 85.7 μM (human HSD1), 295.2 μM (mouse HSD1), and 87.1 μM (human HSD2).

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© 2010 The Pharmaceutical Society of Japan
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