Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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A New Monoterpenoid Glycoside from Myrica esculenta and the Inhibition of Angiotensin I-Converting Enzyme
Nguyen Xuan Nhiem, Phan Van Kiem, Chau Van Minh, Bui Huu Tai, Nguyen Xuan Cuong, Vu Kim Thu, Hoang Le Tuan Anh, Sung-Hoon Jo, Hae-Dong Jang, Young-In Kwon, Young Ho Kim
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キーワード: Myrica esculenta, myresculoside, angiotensin I-converting enzyme inhibitor, antihypertensive
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2010 年 58 巻 10 号 p. 1408-1410

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One new monoterpenoid glycoside, myresculoside (1), and eleven known compounds, were isolated from methanol extract of Myrica esculenta leaves by repeated column chromatography. The effects of these compounds on angiotensin I-converting enzyme (ACE) inhibition were investigated. Compounds 3 and 4 showed the most potent ACE inhibition with rates of 29.97% and 25.63% at concentration of 100 μM, respectively. Compounds 5, 6, and 11 showed weak activity with inhibitory rates of 0.07—1.41% at concentration of 100 μM.

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© 2010 The Pharmaceutical Society of Japan
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